DermaPep
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INCI name : Myristoyl Tripeptide-31, Butylene Gylcol

Aging of skin is an intricate biological process composed of two types, intrinsic and extrinsic aging. While intrinsic aging is an inevitable process, extrinsic aging called photoaging occurs via the clinical and histological consequences of chronic sun exposure, and responsible for the majority of age-related changes, including wrinkles, roughness and mottled hyperpigmentation. These age-related changes are known to be caused by collagen break-down, thus the loss of structural support, by excessive expression and production of the matrix metalloproteinases (MMPs).

Retinoic acid has been widely used both for topical therapy of several skin diseases and to improve the aspect of aging skin. However, topical retinoic acid induces irritation of the skin, which precludes its use in some skin diseases. In addition, retinoic acid has been classified as prescription drug, which also precludes its use as cosmetic active.

In vitro and in vivo study results show that Myristoyl tripeptide-31, a multifunctional retinoic acid-like tripeptide, is very effective in reversing age-related changes, such as wrinkles, mottled hyperpigmentation, and can be a powerful substitute for retinoids without any side effects.

In vitro Efficacy

The efficacy of Dermapep™ A350 has been demonstrated in vitro by measuring MMP1 production on Hs68 fibroblast cell line.

 Anti-wrinkle effect of DermaPep™ A350


DermapepTM A350 significantly decreased MMP-1 production under both non-stimulated and UV-stimulated condition. Dermapep™ A350 also considerably restored the production of type I procollagen from UVA induced damage (supplementary data were not shown).

 Inhibition of melanogenesis and tyrosinase activity
The whitening efficacy of DermaPep™ A350 has been demonstrated in vitro by measuring melanin contents and tyrosinase activity on B26F10 mouse melanoma.


DermaPep™ A350 considerably inhibited melanin synthesis and endogenous tyrosinase activity induced by α-MSH

In vivo Efficacy

 Anti-Aging Efficacy on Asian Skin Type
In a clinical study with 30 Asian healthy female volunteers (Bangkok), aged 40 to 60, 2 % formula containing DermaPep™ A350 had been applied twice daily during 12 weeks on the face area. Evaluation was performed by replica analysis (evaluation of the anti-wrinkle effect) and digital photography. DermaPep™ A350 showed visible anti-wrinkle effect even after 4weeks and very effective in reducing wrinkles in vivo.


Illustrative Picture_Case No.F00667




 Whitening Efficacy on Asian Skin Type
In a clinical study with 30 Asian healthy female volunteers (Bangkok), aged 40 to 60, 2% formula containing DermaPep™ A350 has been applied twice daily during 12 weeks on the face area. Evaluation was performed by chromameter (Chromameter CR-300®, Minolta, Japan) and digital photography. The degree of whitening effect was estimated by following parameters :

L* = Luminosity (Lightness)
ITA˚ = Arc tan ((L*-50)/b*) 180π

Increase of L* and ITA˚ indicates a decrease in skin
pigmentation.

 Illustrative Picture_Case No.F00667



 Lightening Effect of skin tone

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