INCI name: Methyl Undecenoyl Dipeptide-16, Butylene Glycol Dicaprylate/Dicaprate
α-MSH, melanocyte stimulating hormone, is best known as a major factor in the regulation of pigmentation through its unique mechanism. Alpha-MSH involves in the control of tyrosinase activity, melanin synthesis and melanosome transfer. Methyl undecenoyl dipeptide-16 , derivative of Methyl undecenoyl leucinate, interacts with MC1R, a receptor for alpha-MSH, competes against its natural ligand, alpha-MSH and thereby prevents any further activation of melanogenic genes such as tyrosinase, TRP1, TRP2 (DCT), MITF and POMC and finally blocks melanin synthesis. Furthermore,Methyl Undecenoyl dipeptide-16 reduces UVB-induced inflammation and there by provides significant photoprotective effect.
and in vivo
study results show that Methyl undecenoyl dipeptide-16 is far more effective than whitening ingredient such as arbutin.
In vivo clinical study proved that Methyl undecenoyl dipeptide-16 is very effective agent to make your skin safer and brighter.
Mechanism of Whitening Action
In vitro Efficacy
The whitening efficacy of Dermapep™ W220 has been demonstrated in vitro by measuring melanin contents and tyrosinase activity on B26F10 mouse melanoma and human primary melanocytes.
Inhibition of melanogenesis and tyrosinase activity
Dermapep™ W220 inhibits melanin synthesis and endogenous tyrosinase activity stimulated by
In addition, Dermapep™ W220 shows far better depigmenting effect than other known whitening agent such as arbutin.
In vivo Efficacy
Whitening Efficacy on Asian Skin Type
In a clinical study with 30 Asian healthy female volunteers (Bangkok), aged 40 to 60, 2% formula containing DermaPep™ A350 has been applied twice daily during 12 weeks on the face area. Evaluation was performed by chromameter (Chromameter CR-300®, Minolta, Japan) and digital photography.
The degree of whitening effect was estimated by following parameters :
L* = Luminosity (Lightness)
ITA˚ = Arc tan ((L*-50)/b*) 180π
Increase of L* and ITA˚ indicates a decrease in skin
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